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Rabbit Anti-Ras monoclonal antibody, clone TB40-16

Rabbit Anti-Ras monoclonal antibody, clone TB40-16

Cat no: CABT-L564

Supplier: Creative Diagnostics
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Rabbit Anti-Ras monoclonal antibody for WB, IP, FC. Ras superfamily is a protein superfamily of small GTPases, which are all related, to a degree, to the Ras protein subfamily (the key human members of which are KRAS, NRAS, and HRAS). Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein. This antibody is predicted to react with H-Ras, N-Ras and K-Ras.
Catalogue number: CABT-L564
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Conjugates: Unconjugated
Clone: TB40-16
Target: Ras
Isotype: IgG
Clonality: Monoclonal
Storage temp: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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