Home  >  Products  >  RACGAP1 (Rac GTPase-activating Protein 1, Male Germ Cell RacGap, MgcRacGAP, Protein CYK4 Homolg, CYK4, HsCYK-4, KIAA1478, MGCRACGAP)
RACGAP1 (Rac GTPase-activating Protein 1, Male Germ Cell RacGap, MgcRacGAP, Protein CYK4 Homolg, CYK4, HsCYK-4, KIAA1478, MGCRACGAP)

RACGAP1 (Rac GTPase-activating Protein 1, Male Germ Cell RacGap, MgcRacGAP, Protein CYK4 Homolg, CYK4, HsCYK-4, KIAA1478, MGCRACGAP)

Cat no: R0402-01C

Supplier: United States Biological
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Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.[supplied by OMIM] Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 1-3ug/ml Immunohistochemistry (Paraffin): 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: R0402-01C
Reactivities: Human, Bovine, Canine
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Seguin L, Liot C, Mzali R, Harada R, Siret A, Nepveu A, Bertoglio J. CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. Mol Cell Biol. 2009 Jan;29(2):570-81. 2. Grewal S, Carver JG, Ridley AJ, Mardon HJ. Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migration. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16189-94. 3. Tour
Additional info: Recognizes human RACGAP1. Species sequence homology: Bovine and canine.

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