Raf-1 (Ser301) Antibody

Cat no: 252578

Supplier: ABBIOTEC

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Description
Additional Information

The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK. Previous studies have shown that phosphorylation is required for Raf-1 activation. Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf with two sites participating: Ser301 and Ser642.

Catalogue number:	252578
Reactivities:	Human, Mouse, Bovine, Chicken/Bird, Rabbit, Xenopus/Amphibian
Applications:	Western Blot
Size:	0.1 ml
Accession:	P11345
Antigen:	KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser301 of rat raf-1.
Format:	Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody
Isotype:	Rabbit IgG
Additional info:	RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1; Raf1; Raf