RAG2 (4D5) Antibody

Cat no: 252991

Supplier: ABBIOTEC

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Description
Additional Information

RAG2 (V(D)J recombination-activating protein 2) is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a comple, Xenopus/Amphibian, with the product of the adjacent recombination activating gene 1, this comple, Xenopus/Amphibian, can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a si, Xenopus/Amphibian,-bladed propeller in the active core that serves as a binding scaffold for the tight association of the comple, Xenopus/Amphibian, with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Catalogue number:	252991
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 ml
Accession:	P55895
Antigen:	Purified recombinant fragment of human RAG2(350-527aa) e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	4D5
Additional info:	V(D)J recombination-activating protein 2; RAG-2; RAG2