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RAIDD, IN, Blocking Peptide (RIP-associated ICH-1/CED-3-homologous protein with DD, CRADD, Caspase and RIP adapter with DD)

Cat no: R1032-10P

RAIDD, IN, Blocking Peptide (RIP-associated ICH-1/CED-3-homologous protein with DD, CRADD, Caspase and RIP adapter with DD)

Peptide corresponding to amino acids 99 to 117 of human RAIDD 1.\n Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1,2. RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals 1,3. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.

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SPECIFICATIONS

Catalog Number

R1032-10P

Size

50ug

Form

Supplied as a lyophilized powder.

Purity

Purified 60-70%

References

1. Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule. Nature 1997;385:86-89 \n\n2. Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res 1997 57:615-619

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