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RAMP3, Recombinant, Human, aa24-118, His-Tag (Receptor (Calcitonin) Activity Modifying Protein 3, Receptor Activity Modifying Protein 3)

Cat no: 137175

RAMP3, Recombinant, Human, aa24-118, His-Tag (Receptor (Calcitonin) Activity Modifying Protein 3, Receptor Activity Modifying Protein 3)

RAMP3, also known as receptor activity modifying protein 3, is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). It is required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. \n\nSource: \nRecombinant protein corresponding to human RAMP3, fused to His-tag at N-terminal expressed in E.coli.\n\nMolecular Weight: \n~13.0kD (116aa) (MALDI-TOF) \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MRAGGCNETG MLERLPLCGK AFADMMGKVD VWKWCNLSEF IVYYESFTNC TEMEANVVGC YWPNPLAQGF ITGIHRQFFS NCTVDRVHLE DPPDEV\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137175

Size

20ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol, 0.1M NaCl.

Purity

~90% (SDS-PAGE)

References

1. Kuwasako K. et al. (2008) Biochem Biophys Res Commun. 377:109-113. 2. Roh J. et al. (2004) J Biol Chem. 279:7264-7274.

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