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RANBP16 (XPO7, Exportin-7, Exp7, Ran-binding Protein 16, KIAA0745)

RANBP16 (XPO7, Exportin-7, Exp7, Ran-binding Protein 16, KIAA0745)

Cat no: R1069-98B

Supplier: United States Biological
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Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Applications: Suitable for use in ELISA and Western Blot Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.5-1ug/ml, observed in human testis and Hela lysates on ~110kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: R1069-98B
Reactivities: Human, Mouse, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Kutay U, Hartmann E, Treichel N, Calado A, Carmo-Fonseca M, Prehn S, Kraft R, Gorlich D, Bischoff FR. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. J Biol Chem. 2000 Dec 22;275(51):40163-8.
Additional info: Recognizes human XPO7. Species sequence homology: Bovine, canine, mouse and porcine.

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