RANKL, Recombinant, Human (hRANKL, RANKL, TRANCE, TNFSF11) (Carrier free)

Supplier:

United States Biological

Cat no: 137485

RANKL, Recombinant, Human (hRANKL, RANKL, TRANCE, TNFSF11) (Carrier free)

RANKL, also known as TRANCE or OPGL, is a member of the TNF superfamily of ligands. T cells, mammary epithelial cells, and endothelial cells can produce RANKL (1). RANKL is expressed as a type II transmembrane protein or cleaved into a soluble form by extracellular proteases, such as TACE, ADAM10, and matrix metalloproteases (1). Alternative splicing also results in the production of soluble RANKL (1). RANKL signaling is antagonized by osteoprotegerin, which functions as a soluble decoy receptor (2). RANKL plays key roles in mammary gland development and dendritic cell survival and is required for osteoclast differentiation and survival (3-6). Research studies have shown that RANKL deficiencies in both mice and humans are associated with abnormally increased bone density and defects in lymphoid organogenesis (5,6).\n\nSource:\nRecombinant protein corresponding to human RANKL expressed in 293 cells.\n\nMolecular Weight: \n~20.484kD\n\nEndotoxin:\n<0.01ng/1ug\n\nBioactivity:\nDetermined by measuring the ability of hRANKL to induce TRAP activity in Raw 264.7 cells. The ED50 of each lot is 1.5-5ng/ml.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

137485

Size

10ug

Form

Supplied as a lyophilized powder in PBS, pH 7.2, 5% sucrose. Reconstitute in sterile PBS.

Purity

~98% (SDS-PAGE)

References

1. O'Brien, C.A. (2010) Bone 46, 911-9. 2. Lacey, D.L. et al. (1998) Cell 93, 165-76. 3. Wong, B.R. et al. (1997) J Exp Med 186, 2075-80. 4. Fata, J.E. et al. (2000) Cell 103, 41-50. 5. Kong, Y.Y. et al. (1999) Nature 397, 315-23. 6. Conklin, J.L. et al. (1991) Gastroenterology 101, 657-63.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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