RANTES, Recombinant, Mouse (Regulated on Activation, Normal T-cell Expressed and Secreted)

Recombinant Mouse Rantes produced in E. coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton.\n\nBiological Activity: Recombinant Rantes is fully biologically active when compared to standard. The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml.\n\nAA Sequence:\nSPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O, aliquot and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

R1100-07E

Size

5ug

Form

Supplied as a lyophilized powder. Reconstitute with sterile dH2O PBS to 0.1-1mg/ml, which can be further diluted into other aqueous solutions.

Purity

(same/more than) 95% as determined by RP-HPLC; Reducing and non-reducing SDS-PAGE.

References

1. Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. Int J Biol Markers 2006 Oct-Dec;21(4):211-7\n2. Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-alpha) in preterm and term neonates. Pediatr Int 2006 Dec;48(6):586-90\n3. Expression and secretion of RANTES (CCL5) in granulomatous calcified tissue before and after lipopolysaccharide treatment in vivo. Calcif Tissue Int 2007 Jan;80(1):60-7\n4. Platelet-derived chemokine RANTES may be a sign of restenosis after percutaneous coronary intervention in patients with stable angina pectoris. Platelets 2006 Dec;17(8):565-70\n5. Upregulating promoter polymorphisms of RANTES relate to atopic dermatitis. Int J Immunogenet 2006 Dec;33(6):423-8\n6. Simvastatin down regulates mRNA expression of RANTES and CCR5 in posttransplant renal recipients with hyperlipidemia. Transplant Proc 2006 Nov;38(9):2899-904