Rapamycin

Cat no: 029598

Supplier: United States Biological

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Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50=50pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. Solubility: DMSO (25mg/ml) Ethanol (9mg/ml) or Methanol (1mg/ml) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	029598
Size:	100ug
Form:	Supplied as a powder
Purity:	(same/more than)98% (HPLC)
References:	1. Chen, T., et al. 2011. Aging Cell. 10, 908. 2. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.. 3. Braun, W., et al. 1995. FASEB J. 9, 63. 4. Nielsen, F.C., et al. 1995. Nature 377, 358.5. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. 6. Immunol. 156, 493. 7. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. 8. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. 9. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. 10. Kuo, J., et al. 1992. Nature 358, 70. 11. Price, D.J., et al. 1992. Science 257, 973. 12. Heitman, J., et al. 1991. Science 253, 905. 13. Kay, J.E., et al. 1991. Immunology 72, 544. 14. Schreiber, S.L. 1991. Science 251, 283. 15. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. 16. Dumont, F.J., et al. 1990. J. Immunol. 144, 251. 17.Citation Chen, T., et al. 2011. Aging Cell. 10, 908. 18. Yu, YL., et al. 2005. Journal of Biological Chemistry 280, 29533. 19. Vega, R.B., et al. 2004. Molecular and Cellular Biology 24, 8374. 20. Liao, X., et al. 2003. Endocrinology 144, 1656.

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Rapamycin

Cat no: 029598

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