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Rapamycin (FRAP, mTOR Inhibitor, Sirolimus)

Cat no: R1137-01A


Supplier: United States Biological
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Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50=50pM). Solubility: Soluble in DMSO at 200mg/ml or at 50mg/ml in ethanol. TLC: ~90% Elemental Analysis: Calculated C - 67.01% H - 8.71% N - 1.53% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Catalogue number: R1137-01A
Size: 50mg
Form: Supplied as a white to off-white powder.
Purity: ~90%
References: 1. Terada, N., et al., J. Biol. Chem. 268: 12,062-12,068 (1993). 2. Fingar, D.C., et al., J. Biol. Chem. 268: 3005-3008 (1993). 3. Price, D.J., et al., Science 257: 973-977 (1992). 4. Chung, J., et al., Cell 69: 1227-1236 (1992). 5. Morice, W.G., et al., J. Biol. Chem. 268: 3734-3738 (1993). 6. Kay, J.E., et al., Immunology 72: 544-549 (1991). 7. Heitman, J., et al., Science 253: 905-909 (1991). 8. Schwarz, C. & Oberbauer, R., Curr. Opin. Urol. 12: 109-113 (2002). 9. Wells, A.D., et al., Nat. Med. 5: 1303-1307 (1999). 10. Li, Y., et al., Nat. Med. 5: 1298-1302 (1999).

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