Rapsyn (receptor-associated protein of the synapse) is a peripheral membrane protein that has a close association to acetylcholine receptors (AChRs). Studies have shown that mice with a mutated rapsyn gene were unable to form AChR clusters, resulting in birth from respiratory failure death soon after. Other mutations affecting the activity of rapsyn can lead to the formation of the neuromuscular disease myasthenia gravis.
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
ELISA: 1:128,000
Western Blot: 0.3-1ug/ml, observed in human skeletal muscle lysates on ~38kD bands
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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