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Ras-GRF1 (F912) Peptide

Ras-GRF1 (F912) Peptide

Cat no: BS1788P


Supplier: Bioworld Technology, Inc.
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A critical step in signal transduction responses to stimulation of cell surface receptors by their ligands involves the accumulation of Ras proteins in their active GTP-bound state. To reach their active GTP-bound state, Ras proteins must first release bound GDP, a rate limiting step mediated by a guanine nucleotide releasing factor (GRF). The mammalian Ras p21 GRF protein has been designated Ras-GRF1 p140. Ras-GRF1 accelerates release of GDP from H- and N-Ras p21 protein in vitro, but not from the related Ral A or Cdc42Hs GTP-binding proteins.Ras-GRF2 p135 is highly homologous to Ras-GRF1 p140 except in the region between the REM and CDC25 domains and appears to function similarly to Ras-GRF1 p140.
Catalogue number: BS1788P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q13972
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Ras-GRF1 (F912). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide; exchange factor CDC25; RASGRF1; CDC25; GNRP; GRF1
Additional info: This peptide can be used with studies using BS1788 Ras-GRF1 (F912) pAb.

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