Rat anti Mouse C5 monoclonal antibody, clone 306219

Cat no: CABT-L277

Supplier: Creative Diagnostics

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Rat Anti-Mouse C5 monoclonal antibody for ELISA(Cap), WB. Mouse Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as Anaphylatoxins. C5a is a 77 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 alpha-chain. Mouse C5a has four alpha-helices, plus three intrachain disulfide bonds that create a triple loop structure. In serum, proteolytic processing removes the C-terminal arginine, creating a low activity C5a desArg77 molecule. Mouse C5a shares 60% and 82% aa sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. Alternatively, it may also bind to a nonsignaling GPCR termed C5L2 whose function is yet to be determined.

Catalogue number:	CABT-L277
Reactivities:	Mouse
Hosts:	Rat
Conjugates:	Unconjugated
Clone:	306219
Gene:	15139
Target:	C5
Isotype:	IgG2A
Clonality:	Monoclonal
Storage temp:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

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Rat anti Mouse C5 monoclonal antibody, clone 306219

Cat no: CABT-L277

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