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Rat Anti-Mouse CLEC9A monoclonal anyibody, clone 8I22

Cat no: CABT-L1107


Supplier: Creative Diagnostics
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Rat Anti-Mouse CLEC9A monoclonal anyibody for ELISA, IF, IP, WB, FC. CD370 (CLEC9A), also known as DNGR1, is a 264 amino acid (aa) type II transmembrane glycoprotein which belongs to the C-type lectin superfamily. It contains a 208 aa extracellular region with a single carbohydrate recognition domain (CRD) and a cytoplasmic segment (35 aa) bearing an immunoreceptor tyrosine-based activation motif (ITAM). In mice, CLEC9A is strictly expressed on CD8a-positive dendritic cells and plasmacytoid dendritic cells. It recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.
Catalogue number: CABT-L1107
Reactivities: Mouse
Hosts: Rat
Applications: ELISA
Conjugates: Unconjugated
Clone: 8I22
Target: CLEC9A
Isotype: IgG1
Clonality: Monoclonal
Storage temp: The antibody solution should be stored undiluted between 2°C and 8°C.

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