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Rat Anti-Mouse CLEC9A monoclonal anyibody, clone 8I22

Cat no: CABT-L1107

Rat Anti-Mouse CLEC9A monoclonal anyibody, clone 8I22

Rat Anti-Mouse CLEC9A monoclonal anyibody for ELISA, IF, IP, WB, FC. CD370 (CLEC9A), also known as DNGR1, is a 264 amino acid (aa) type II transmembrane glycoprotein which belongs to the C-type lectin superfamily. It contains a 208 aa extracellular region with a single carbohydrate recognition domain (CRD) and a cytoplasmic segment (35 aa) bearing an immunoreceptor tyrosine-based activation motif (ITAM). In mice, CLEC9A is strictly expressed on CD8a-positive dendritic cells and plasmacytoid dendritic cells. It recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.

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SPECIFICATIONS

Catalog Number

CABT-L1107

Applications

ELISA

Hosts

Rat

Reactivities

Mouse

Conjugates

Unconj

Clone

8I22

Target

CLEC9A

Isotype

IgG1

Clonality

Monoclonal

Storage Temp

The antibody solution should be stored undiluted between 2В°C and 8В°C.

SUPPLIER INFO

Creative Diagnostics

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