Home  >  Products  >  Rcan2, Recombinant, Mouse, aa2-197, His-tag (Calcipressin-2, Calcineurin Inhibitory Protein ZAKI-4, Down Syndrome Candidate Region 1-like Protein 1, Myocyte-enriched Calcineurin-interacting Protein 2, MCIP2, Regulator of Calcineurin 2, Dscr1l1, Zaki4)
Rcan2, Recombinant, Mouse, aa2-197, His-tag (Calcipressin-2, Calcineurin Inhibitory Protein ZAKI-4, Down Syndrome Candidate Region 1-like Protein 1, Myocyte-enriched Calcineurin-interacting Protein 2, MCIP2, Regulator of Calcineurin 2, Dscr1l1, Zaki4)

Rcan2, Recombinant, Mouse, aa2-197, His-tag (Calcipressin-2, Calcineurin Inhibitory Protein ZAKI-4, Down Syndrome Candidate Region 1-like Protein 1, Myocyte-enriched Calcineurin-interacting Protein 2, MCIP2, Regulator of Calcineurin 2, Dscr1l1, Zaki4)

Cat no: 149777

Supplier: United States Biological
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Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Source: Recombinant protein corresponding to mouse RCAN2 Isoform 2, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~26kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 149777
Size: 50ug
Form: Supplied as a liquid in 100mM sodium phosphate, 10mM Tris, 500mM sodium chloride, 25mM imidazole, 2mM magnesium chloride, 10% glycerol.
Purity: ~95%
References: 1. Miyazaki T, Kanou Y, Murata Y, et al. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J. Biol. Chem. 1996; 271:14567-71. 2. Rothermal B, Vega RB, Yang J, et al. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 2000; 275:8719-25. 3. Cao X, Kambe F, Miyazaki Y, et al. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. Biochem. J. 2002; 367:459-66. 4. Fuentes JJ, Genesca L, Kingsbury TJ, et al. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet. 2000; 9:1681-90.

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