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Rebeccamycin

Cat no: R1281-15


Supplier: United States Biological
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Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. It displays a selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin are currently in several clinical trials for cancer therapy. Purity: >99% by HPLC Solubility: Soluble in THF or DMSO. Poorly soluble in methanol and water. Related to: Staurosporine, Antibiotic UCN-01, Antibiotic UCN-02
Catalogue number: R1281-15
Size: 500ug
Purity: >99% by HPLC
References: 1. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Long B.H. et al. Curr. Med. Chem. Anticancer Agents 2002, 2, 255. 2. Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin. Woo M.H. et al. J. Biol. Chem. 2002, 277, 3813. 3. Production and biological activity of rebeccamycin, a novel antitumor agent. Bush J.A. et al. J. Antibiot. 1987, 40, 668.

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