Recombinant Human CCL17 (TARC) (carrier-free)

Cat no: 573808

Supplier: BioLegend

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Description
Additional Information

CCL17 was initially isolated from phytohemagglutinin-stimulated PBMC. CCL17 is constitutively expressed in the thymus and, under activation, in several cell types. CCL17-mediated recruitment of Th2 cells and CLA+ CD4+ T cells plays a key role in allergic diseases like atopic dermatitis, allergic asthma, allergic rhinitis, and allergic contact dermatitis. In addition, CCL17 has been detected in idiopathic pulmonary fibrosis. Also, CCL17 and CCL22 secreted by DC seem to mediate the recruitment of regulatory T cells to sites of inflammation in patients with chronic hepatitis. CCL17 is upregulated by several combinations of cytokines: TNFalpha, IL-4, and IFNgamma in bronchial epithelial cells; TGFbeta1, TNFalpha, and IFNgamma in human keratinocyte cell lines; and histamine and prostaglandin E2P in immature DC.

Catalogue number:	573808
Size:	500 microg
Gene:	6361
Storage buffer:	Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status:	RUO
Shipping temp:	Blue Ice
Storage temp:	-20 C or -70 C
Alternative names:	Thymus and activation-regulated chemokine (TARC), Small-inducible cytokine 17 (SCYA17)