Recombinant Human CCL21 (6CKine) (carrier-free)

Cat no: 582206

Supplier: BioLegend

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Description
Additional Information

CCL21 is a CC chemokine highly expressed in lymph nodes. CCL21 is only 32% identical to CCL19 at the amino acid level; nevertheless, these chemokines bind to the same receptor CCR7. CCL21 has a unique extension of about 30 amino acids with two extra cysteine residues in its carboxyl terminus. CCL21 is expressed in synovial tissue in rhematoid arthritis (RA), and it has been suggested that CCL21, but not CCL19, induces human microvascular endothelial cell (HMVEC) migration and/or tube formation. In addition, it has been reported that sustained high concentrations of either soluble or immobilized CCL19 and CCL21 inhibit T cell proliferation and IL-2 secretion.

Catalogue number:	582206
Size:	100 microg
Gene:	6366
Storage buffer:	Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1% BSA or HSA. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status:	RUO
Shipping temp:	Blue Ice
Storage temp:	-20 C or -70 C
Alternative names:	6CKine; Secondary lymphoid tissue chemokine, SLC; Exudos 2; Small inducible cytokine subfamily B, member 21, SCYA21