Recombinant Human IL-1alpha (carrier-free)

Cat no: 570006

Supplier: BioLegend

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Description
Additional Information

IL-1 was isolated from human blood that had been exposed to a pathogenic bacterium. IL-1 is a pyrogen, and it is an activating factor for lymphocytes. It also damaged joints and influenced liver proteins (2). IL-1alpha binds to the cell surface type I and II IL-1 receptors (IL-1RI and IL-1RII). IL-1 and -beta and IL-1RA can compete for binding to these receptors. However, only IL-1RI, not IL-1RII, is functional because IL-1RII lacks a cytoplasmic domain and is thus unable to transmit signals to downstream steps (3). IL-1alpha is expressed by cancer cells and promotes angiogenesis and metastasis of pancreatic cancer and human gastric cancer cell lines (4). In addition, IL-1 induced the expression of VEGF in colon cancer (5).

Catalogue number:	570006
Size:	100 microg
Gene:	3552
Dilutions:	Use when high specific biological activity is required.
Storage buffer:	Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. For long term storage, aliquot into polypropylene vials and store in a manual defrost freezer. Avoid repeated freeze/thaw cycles.
Regulatory status:	RUO
Shipping temp:	Blue Ice
Storage temp:	-20 C or -70 C
Alternative names:	Interleukin-1alpha, LAF, EP, LEM, MCF/MNCF