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Recombinant human IL-1beta (carrier-free)

Recombinant human IL-1beta (carrier-free)

Cat no: 579408

Supplier: BioLegend
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IL-1beta in humans and mice does not encode a typical signal peptide and, as a result, newly synthesized pro-IL-1beta accumulates within the cytoplasm of activated monocytes and macrophages (1). Conversion of the inactive pro-IL-1beta to its mature form requires the proteolytic action of IL-1beta-converting enzyme (ICE), also termed caspase-1 (2). Secretion of mature IL-1beta from LPS-activated monocytes/macrophages is not a constitutive process. These cells must encounter a secondary stimulus that specifically activates the posttranslational processing events (2). Moreover, owing to its pro-inflammatory nature, IL-1beta is regarded as a tumor-promoting cytokine. In fact, enhanced tumor metastasis and angiogenesis has been observed under the influence of IL-1beta (3). IL-1beta is able to facilitate tumor progression in murine models of lung cancer. In addition, upregulation of metastasis and tumor angiogenesis by IL-1beta has been associated with increased activity of matrix metalloproteinases and expression of the pro-angiogenic molecule hepatocyte growth factor (4).
Catalogue number: 579408
Size: 500 microg
Gene: 147720
Dilutions: Use when high specific biological activity is required.
Storage buffer: Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. For long term storage, aliquot into polypropylene vials and store in a manual defrost freezer. Avoid repeated freeze/thaw cycles.
Regulatory status: RUO
Shipping temp: Blue Ice
Storage temp: -20 C or -70 C
Alternative names: Interleukin-1beta, Catabolin, H1, IFNbeta-inducing factor, OAF
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