Recombinant Human IL-33 (carrier-free)

Cat no: 581808

Supplier: BioLegend

0 reviews | Write a Review Pencil

Description
Additional Information

IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1beta. IL-33, IL-1beta, and IL-18 are synthesized as biologically inactive precursors and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and, subsequently, activates NF-kappaB and MAPK pathways via identical signalling events to those observed for IL-1beta. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associate with chromatin and exhibit transcriptional regulatory properties.

Catalogue number:	581808
Size:	500 microg
Gene:	90865
Storage buffer:	Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, DPBS, HBSS, or EBSS) containing carrier protein such as 1% BSA or HSA or 10% FBS. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status:	RUO
Shipping temp:	Blue Ice
Storage temp:	-20 C or -70 C
Alternative names:	Il-1f11, Nuclear factor from high endothelial venules (NF-HEV)