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Recombinant Human IL-34 (carrier-free)

Recombinant Human IL-34 (carrier-free)

Cat no: 577902

Supplier: BioLegend
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Human IL-34 shares a sequence identity of 99.6%, 72% and 71% with chimpanzee, rat, and mouse IL-34, respectively, on the amino acid level. The IL-34 gene is syntenic in the human, chimpanzee, rat, and mouse genomes. IL-34 has no apparent consensus structural domain or motif, and does not share sequence homology with M-CSF; nevertheless, it binds to the CSFR. These two cytokines are not identical in biological activity and signal activation. IL-34 and CSF show an equivalent ability to support cell growth or survival. However, these cytokines have differing ability to induce the production of chemokines (MCP-1 and eotaxin-2) in primary macrophages, the morphological change in TF-1-fms cells, and the migration of J774A.1 cells. The use of monoclonal antibodies against the CSFR suggests a differential domain binding in the receptor to IL-34 and CSF and, as a result, different bioactivities and signal activation kinetics/strength are produced for these cytokines.
Catalogue number: 577902
Size: 10 microg
Gene: 146433
Storage buffer: Unopened vial can be stored at 4C for three months or from -20C to -70C for six months. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status: RUO
Shipping temp: Blue Ice
Storage temp: -20 C or -70 C
Alternative names: IL34, C16orf77 homolog
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