Home  >  Products  >  Recombinant Mouse CCL9 (MIP-1gamma) (carrier-free)
Recombinant Mouse CCL9 (MIP-1gamma) (carrier-free)

Recombinant Mouse CCL9 (MIP-1gamma) (carrier-free)

Cat no: 586208

Supplier: BioLegend
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Mouse CCL9 was initially cloned from cDNA libraries of BaF3 and RAW 264.7 cells. It is constitutively expressed in a big variety of tissues, including the follicle-associated epithelium overlaying the dome regions of the Peyer’s patches. Using CCR6 -/- mice, it was shown that CCL9 recruits CD11b+ dendritic cells (DCs) to the sub-epithelial dome regions of the Peyer’s patch. This data showed that the CCL20/CCR6 pair is not absolutely required for the recruitment of CD11b+ DCs to that region. In addition, CCL9 is induced in Raw264.7 and bone marrow cells by RANKL, and the use of this osteoclastogenesis model suggested that CCL9 stimulates the activation and survival of mature osteoclasts. The expression of CCL9 and CCR1 in osteoclasts suggests a role for CCL9 in bone resorption. Additional data have shown that activation of TLR-9 in microglia with unmethylated CpG oligodeoxynucleotides (CpG-ODNs) induces production of CCL9 and expression of CCR1. In addition, Retinoid X Receptor alpha (RXRa) plays a role in the regulation of the innate immune response, and the disruption of this nuclear receptor, in peritoneal macrophages, induces a decrease in CCL6 and CCL9 in vivo, correlating with impaired leukocyte recruitment to inflammatory sites and prolonged survival in sepsis.
Catalogue number: 586208
Size: 500 microg
Gene: 20308
Storage buffer: Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1% BSA or HSA. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status: RUO
Shipping temp: Blue Ice
Storage temp: -20 C or -70 C
Alternative names: CCF18, macrophage inflammatory protein (MIP)-related protein-2 (MRP-2), Scya10, Scya9
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave