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Recombinant Mouse CXCL2 (MIP-2) (carrier-free)

Recombinant Mouse CXCL2 (MIP-2) (carrier-free)

Cat no: 582508

Supplier: BioLegend
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CXCL2 is an ELR CXC chemokine, and it is structurally and functionally related to GRO1 (CXCL1), GRO3 (CXCL3), and interleukin-8 (CXCL8). CXCL2 binds to the CXCR2 receptor, and this receptor is shared with other ELR CXC chemokines (CXCL1, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8). CXCL2 is highly expressed in esophageal squamous cell carcinoma (ESCC), and it has been detected in serum of patients with this disease. Also, CXCL1, CXCL2, and CXCL3 have been shown to be highly expressed in patients with malignant melanoma. In addition, CXCL2 and CXCL1 are up-regulated in the central nervous system in multiple sclerosis (MS) and in the animal model of experimental autoimmune encephalomyelitis (EAE). In EAE, it has been shown that transfer of encephalitogenic CD4+ Th17 cells induce CXCL1 and CXCL2 transcription in the spinal cords of naïve, syngeneic recipients. IL-17 is a potent inducer of ELR+ CXC chemokines in MS and EAE. In fact, it has been showed that CXCL1 and CXCL2 are up-regulated in the preclinical and clinical stages of EAE. In addition, it has been shown that CXCL1 and CXCL2 are secreted by ephithelial cells in bone marrow, and CXCL2 is secreted by endothelial cells during G-CSF-induced neutrophil mobilization.
Catalogue number: 582508
Size: 500 microg
Gene: 20310
Storage buffer: Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1% BSA or HAS. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status: RUO
Shipping temp: Blue Ice
Storage temp: -20 C or -70 C
Alternative names: Gro2 oncogene, Grobeta, Macrophage inflammatory protein (MIP-2), MIP-2a, Small inducible cytokine subfamily B, member 2 (Scyb2), melanoma growth stimulatory activity (MGSA)
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