Recombinant mouse IL-1beta (carrier-free)

Interleukin-1 is a key mediator of inflammation, with pleiotropic effects on several cells and signaling pathways. The activity defined as IL-1 reflects the function of 2 molecules, IL-1alpha and IL-1beta. IL1A encodes IL-1alpha, which is cell-bound, and IL1B encodes IL-1beta, a secreted cytokine (1). IL-1alpha and IL-1beta are synthesized as 31-kD precursors and are processed by proteases to their mature 17-kD forms. IL-1beta-converting enzyme cleaves the inactive IL-1beta Precursor and ProIL-1alpha is processed by calpain (4). IL-1beta is a tumor-promoting cytokine, and it enhances tumor metastasis and angiogenesis. IL-1beta is able to facilitate tumor progression in murine models of lung cancer. Upregulation of metastasis and tumor angiogenesis by IL-1beta has been associated with increased activity of matrix metalloproteinases and expression of the pro-angiogenic molecule hepatocyte growth factor (5).

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SPECIFICATIONS

Catalog Number

575108

Size

500 microg

Gene Id

16176

Dilutions

Use when high specific biological activity is required.

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. For long term storage, aliquot into polypropylene vials and store in a manual defrost freezer. Avoid repeated freeze/thaw cycles.

Alternative Names

Interleukin-1beta, Catabolin, H1, IFNbeta-inducing factor, OAF

Regulatory Status

RUO