Recombinant mouse IL-27 (carrier-free)

Cat no: 577402

Supplier: BioLegend

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Description
Additional Information

IL-27 is a heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, an IL-12p35-related polypeptide. IL-27 can be allocated to the IL-6/IL-12 superfamily of cytokines which include also IL-23. This family is defined based on similarities in the structural motifs of the ligands, such as a common four-helix bundle, their receptors, which contain a hematopoietin receptor domain. IL-27 signaling occurs via a receptor complex composed of the signal transducing receptor chains WSX-1 and glycoprotein (gp) 130. Whereas WSX-1 is the IL-27–specific receptor chain, gp130 is the common receptor subunit of IL-6 type cytokines. IL-27 signaling in naïve CD4+ T cells leads to activation and phosphorylation of STAT1 and STAT3.

Catalogue number:	577402
Size:	10 microg
Gene:	246779
Storage buffer:	Unopened vial can be stored at -20C for six months or at -70C for one year. After dilution, the cytokine can be stored at 4C for one month or -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.
Regulatory status:	RUO
Shipping temp:	Blue Ice
Storage temp:	-20 C or -70 C
Alternative names:	Interleukin 27, IL-27p28 (IL-30), EBI3