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Recombinant Rat IL-2 (carrier-free)

Recombinant Rat IL-2 (carrier-free)

Cat no: 579504

Supplier: BioLegend
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Interleukin 2 was discovered through its function as a T cell growth factor (TCGF). IL-2 binds to IL-2 receptor which is expressed in T and B cells, thymocytes, and NK cells. The IL-2 receptor comprises three distinct components: the alpha-chain, which is cytokine specific, and the beta- and gammac-subunits which are share with the IL-15 receptor. In addition, the gammac-subunit is a component of a series of other cytokine receptors, these being members of the gammac cytokine receptor family (IL-4, IL-7, IL-9, and IL-21) (3). IL-2 signaling may play a major role in the differentiation of regulatory T cells (4). IL-2, IL-15, and IL-7 can all support NK cell differentiation; nevertheless, analyses of IL-2(-/-), IL-2Ralpha(-/-) mice fail to exhibit significant defects in NK cell development. This data suggest that IL-2 might have a redundant role in NK cell differentiation (4).
Catalogue number: 579504
Size: 25 microg
Gene: 116562
Dilutions: Use when high specific biological activity is required.
Storage buffer: Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. For long term storage, aliquot into polypropylene vials and store in a manual defrost freezer. Avoid repeated freeze/thaw cycles.
Regulatory status: RUO
Shipping temp: Blue Ice
Storage temp: -20 C or -70 C
Alternative names: Interleukin-2, TCGF, EDF, KHF, MAF-CI, TDF
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