Resistin (mouse) BioAssay(TM) ELISA Kit (FIZZ3, Found in Inflammatory Zone 3, ADSF, Adipose Tissue-Specific Secretory Factor)

Resistin (FIZZ3; ADSF; Adipose tissue-specific secretory factor) is a 12.5kD cysteine-rich adipocytokine. In rodents, increased resistin-levels impair insulin action, while genetic ablation or down-regulation of the resistin gene improves insulin sensitivity. In humans most reports identified inflammatory cells and bone marrow-derived cells as the main source of resistin, indicating a role in inflammatory responses. Plasma resistin levels were shown to be associated with C-reactive protein (CRP), inflammatory bowel disease, Crohn's disease, atherosclerosis and acute pancreatitis. Atherosclerosis and obesity are increasingly viewed as chronic inflammatory conditions. Circulating resistin levels were reported to be increased in obesity and diabetes.\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: +4 degrees C

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SPECIFICATIONS

Catalog Number

045245

Size

96Tests

References

Product Reference: \n?Sp1 mediates repression of the resistin gene by PPARgamma agonists in 3T3-L1 adipocytes: SS. Chung, et al.; BBRC 348, 253 (2006)\n?Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Defi cient Mice: H. Hashimoto, et al.; Exp. Clin. Endocrinol. Diabetes 117, 577 (2009)\n?

Additional Info

Detects mouse resistin. Weakly cross-reacts (<40%) with rat resistin. Does not cross-react with human resistin, mouse RELM-alpha, mouse RELM-beta, rat RELM-alpha, mouse leptin or mouse adiponectin.

Alternative Names

FIZZ3, Found in Inflammatory Zone 3, ADSF, Adipose Tissue-Specific Secretory Factor