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Reticulol (6,8-Dihydroxy-7-methoxy-3-methylisocoumarin)

Reticulol (6,8-Dihydroxy-7-methoxy-3-methylisocoumarin)

Cat no: R1650-35

Supplier: United States Biological
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Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol has also been demonstrated to cause a dose dependent inhibition of lung metastasis in the B16F10 melanoma model. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO
Catalogue number: R1650-35
Size: 1mg
Purity: >95% by HPLC
Alternative names: 6,8-Dihydroxy-7-methoxy-3-methylisocoumarin
References: 1. Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Lim D.S. et al. Chemotherapy 2003, 49, 257. 2. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Lim D.S. et al. Chemotherapy 2003, 49, 146. 3. Reticulol, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. Furutani Y. J. Antibiot. 1975, 28, 558. 4. Reticulol, a new metabolic isocoumarin. Mitscher L.A. et al. Experientia 1964, 20, 258.

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