Retinoblastoma Binding Protein 7 (RbBP7, RbBP-7, Chromatin Assembly Factor 1 Subunit C, G1/S Transition Control Protein Binding Protein RbAp46, Histone Acetyltransferase Type B Subunit 2, Histone Binding Protein RbBP7, MGC138867, MGC138868, MGC53418, MSI1

RBBP7 is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. RBBP7 is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with the BRCA1 tumor-suppressor and may have a role in the regulation of cell proliferation and differentiation.\n\nApplications: \nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot:1:10,000-50,000\nImmunohistochemistry (Paraffin):1:500-1000\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nWestern Blot: HeLa, 293T, Y79, HepG2 cell lysates \nImmunohistochemistry: Human tonsil tissue, human urothelium cell \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.\n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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