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Retinoic acid (all-trans-Retinoic acid, ATRA, Tretinoin, Vitamin A acid, 15-Apo-beta-caroten-15-oic acid)

Cat no: R1690-01E

Retinoic acid (all-trans-Retinoic acid, ATRA, Tretinoin, Vitamin A acid, 15-Apo-beta-caroten-15-oic acid)

Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retin5/25goic acid primes embryonic stem cells to become neurons.\n\nSolubility:\nDMSO\n\nLoss on Drying: (same/less than)0.5%\n\nSulfated Ash: (same/less than)0.1%\n\nHeavy Metals: (same/less than)0.002%\n\nLimit of Isotretinoin: (same/less than)5%\n\nStorage and Stability:\nPowder may be stored at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light and temperature sensitive.

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SPECIFICATIONS

Catalog Number

R1690-01E

Size

1g

Form

Supplied as a yellow to light orange lyophilized powder

Purity

98-102% (HPLC)

References

1. Nadin, L., Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes. Biochem. Pharmacol. 58, 1201-1208, (1999). 2. Simoni, D., and Tolomeo, M., Retinoids, apoptosis and cancer. Curr. Pharm. Des. 7, 1823-1837, (2001). 3. Napoli, J.L., Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clin. Immunol. Immunopathol. 80, S52-S62, (1996). 4. Sasai, Y., Generation of dopaminergic neurons from embryonic stem cells. J. Neurol. 249, II 41-II 44, (2002)

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