Retinoic Acid Receptor alpha (RAR alpha)

The retinoic acid receptors (RARs) are family of nuclear receptors that mediates effects of retinoic acid (RA, acidified form of vitamin A), a non-steroid hormone involved in cell proliferation, differentiation, and apoptosis (1). Three isoforms of RAR exists (RAR alpha, beta, and gamma) and forms a heterodimer with RXRs (retinoid X receptor, a distant related receptor). When bound to RA, RARs acts as transcription factors and binds to thyroid hormone response element or RA response element (RARE), activating gene expression (2). RAR alpha has been implicated as important biomedical marker in the pathogenesis of acute promyelocytic leukemia (APL) (3).\n\nApplications: \nSuitable for use in Western Blot, Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:500-1:1000\nFlow Cytometry: 1:50\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

R1691-01D

Size

100ul

Applications

FC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1. Melnick, A. & Licht, J. D. Blood 93:3167-3215, 1999. 2. Gu BW et al. PNAS 99:7640-7645, 2002.\n3. Warrell RP et al N. Engl. J. Med. 329:177-189, 1993.

Additional Info

Recognizes human RAR alpha. Species Crossreactivity: mouse.