Retinol Binding Protein 4, Recombinant, Human (RBP4, Plasma Retinol-binding Protein, PRBP, RBP, PRO2222)

Retinol binding protein 4 (RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. This protein was found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the rbp-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. RBP- 4 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 184aa and having a molecular mass of 21kD. The Retinol Binding Protein-4 is purified by proprietary chromatographic techniques.\n\nSource:\nRecombinant corresponding to human RBP4 expressed in E. coli.\n\nMolecular Weight:\n~21kD\n\nAA Sequence:\nMERDCRVSSF RVKENFDKAR FSGTWYAMAK KDPEGLFLQD NIVAEFSVDE TGQMSATAKGRVRLLNNWDV CADMVGTFTD TEDPAKFKMK YWGVASFLQK GNDDHWIVDT DYDTYAVQYS CRLLNLDGTC ADSYSFVFSR DPNGLPPEAQ KIVRQRQEEL CLARQYRLIV HNGYCDGRSE RNLL\n\nBiological Activity:\nImmune reactive in ELISA using monoclonal anti CD4 in gpl2O capture ELISA assays.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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