Retnlb, Recombinant, Mouse (Resistin-like beta, Cysteine-rich Secreted Protein A12-beta, Cysteine-rich Secreted Protein FIZZ2, RELMbeta, Fizz2, 9030012B21Rik)

RELMbeta (Resistin-like molecule beta/FIZZ2) is an 18kD disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMbeta, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELMbeta is highly homologous to that of the adipose-derived cytokine Resistin and RELMbeta. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMbeta is an 18kD, consisting of two 83aa residue chains.\n\nAA Sequence:\nMQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA\n\nCrossreactivity:\nMouse, Pig Intestinal Worm, Parasite\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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