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Reveromycin B

Reveromycin B

Cat no: R1988-01

Supplier: United States Biological
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Reveromycin B is an much less active analogue of reveromycin A formed by rearrangement of the 6to6 spiroketal to a 5to6 spiroketal. Lacking much of the biological activity of reveromycin A, the reveromycin B is a useful negative control in resolving the mode of action of this class. Purity: >90% by HPLC Solubility: Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO, avoid acidic conditions. Related to: Reveromycin A, Reveromycin C, Reveromycin D
Catalogue number: R1988-01
Size: 250ug
Purity: >90% by HPLC
References: 1. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. Antibiot. 1992, 45, 1414. 2. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y. et al. J. Biol. Chem. 2002, 277, 28810.

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