A cell-permeable, potent, and selective human A3 adenosine receptor antagonist (Ki = 0.66uM) and an aurora kinase inhibitor (IC??'s of 30-550 nM for blast colony formation assay). Induces dedifferentiation in murine C2C12 myoblasts. The cells were also shown to regain multipluripotency following removal of the compound.
Solubility:
DMSO (~7-10mg/ml)
Molecular Weight:
~393.49
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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