RGPD5, NT (RANBP2-like and GRIP Domain-containing Protein 5/6, Ran-binding Protein 2-like 1/2, RanBP2-like 1/2, RanBP2L1, RanBP2L2, Sperm Membrane Protein BS-63, RANBP2L1, RGP5, RGP7, RGPD7, RGPD6, RANBP2L2, RGP6)

The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.\n\nApplications:\nSuitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1ug/ml\nImmunofluorescence: 20ug/ml\nImmunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman Thymus Tissue Lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

146268

Size

100ug

Applications

ELISA, IF, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Nothwang HG, Rensing C, Kubler M, et al. Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on chromosome 2q11-q12. Genomics 1998; 47:383-92.\n2. Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008; 319:921-6. 3. Wang LF, Zhu HD, Miao SY, et al. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch. Androl. 1999; 42:71-84.

Additional Info

Recognizes human RGPD5.