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RGS16, Recombinant, Human (Regulator of G Protein Signaling 16, Regulator of G-protein Signalling 16, RGS-16, A28-RGS14, A28-RGS14P, HGNC:9997, hRGS-r, Retinally Abundant Regulator of G Protein Signaling, Retinal-specific RGS, RGSR, RGS-R)

Cat no: R1996-32H

RGS16, Recombinant, Human (Regulator of G Protein Signaling 16, Regulator of G-protein Signalling 16, RGS-16, A28-RGS14, A28-RGS14P, HGNC:9997, hRGS-r, Retinally Abundant Regulator of G Protein Signaling, Retinal-specific RGS, RGSR, RGS-R)

RGS16, also known as regulator of G-protein signaling 16, belongs to 'regulator of G protein signaling' family and negatively regulates G protein coupled receptor signalling. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP bound form. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Recombinant RGS16 protein was expressed in E. coli.\n\nSource: \nRecombinant corresponding to aa1-202 of human RGS16 6x His tagged expressed in E. coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE KKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETRELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS HT\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

R1996-32H

Size

50ug

Applications

WB

Form

Supplied as a liquid in PBS, pH 7.4, 20% glycerol, 0.1M NaCl.

Purity

~ 90% (SDS-PAGE). Purified by using conventional chromatography techniques.

References

1. Chen C., et al. (1997) J Biol Chem. 272(13):8679-85 2. Derrien A., et al. (2001) J Biol Chem. 276(51):48532-8

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