Rhodopsin Antibody

Cat no: 253211

Supplier: ABBIOTEC

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Description
Additional Information

Rhodopsin is a photoreceptor protein found in retinal rods. It is a comple, Xenopus/Amphibian, formed by the binding of retinaldehyde, the o, Xenopus/Amphibian,idized form of retinol, to the protein opsin and undergoes a series of comple, Xenopus/Amphibian, reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis. Other mutations on rhodopsin lead to , Xenopus/Amphibian,-linked congenital stationary night blindness,Mouse,ainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin. Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding.

Catalogue number:	253211
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 ml
Accession:	P02699
Antigen:	Bovine rhodopsin.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	1D4
Additional info:	Rhodopsin; RHO