RICTOR (7B3) Antibody

Cat no: 253050

Supplier: ABBIOTEC

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Description
Additional Information

RICTOR (Rapamycin-insensitive companion of mTOR) is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals. mTOR is a large protein kinase with two different comple, Xenopus/Amphibian,es mTORC1 and mTORC2. One comple, Xenopus/Amphibian, contains mTOR, G(B)L and raptor, which is a target of rapamycin. The other comple, Xenopus/Amphibian,, insensitive to rapamycin, includes mTOR, G(B)L, Sin1 and rictor. The mTOR-rictor comple, Xenopus/Amphibian, phosphorylates Ser473 of Akt/PKB in vitro. This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes. This comple, Xenopus/Amphibian, has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .

Catalogue number:	253050
Reactivities:	Human, Mouse
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	Q6R327
Antigen:	Purified recombinant fragment of human RICTOR e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	7B3
Additional info:	Rapamycin-insensitive companion of mTOR; AVO3 homolog; hAVO3; KIAA1999; RICTOR