RIG-I (Retinoic Acid Inducible Gene 1 Protein, RIG-I, Dead Box Protein 58, ddx58)

RIG-I is a receptor found in the cytoplasm that recognises viral RNA from replicating viruses in infected cells. Upon activation with intracellular RNA, a cascade is triggered resulting in the activation of NF-kappa-B, and the eventual induction of antiviral cytokines such as IFN-beta and RANTES. RIG-I is essential for the production of interferons in response to RNA viruses and as such play a key role in innate immunity.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: Optimal dilutions to be determined by the researcher.\n\nRecommended Secondary Antibodies:\nRabbit Anti Rat IgG HRP\nRabbit Anti Rat IgG FITC\nRabbit Anti Rat IgG RPE\nRabbit Anti Rat IgG HRP\nGoat Anti Rat IgG FITC\nGoat Anti Rat IgG (MOUSE ADSORBED) DyLight(TM)488, DyLight(TM)549, DyLight(TM)649\nGoat Anti Rat IgG HRP\nGoat Anti Rat IgG RPE\nGoat Anti Rat IgG Biotin, FITC\nGoat Anti Rat IgG Alk. Phos.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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