RLN2, CT (RLN2, Prorelaxin H2, Relaxin B chain, Relaxin A chain)

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

041072

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)\nVogel, I., et al. In Vivo 23(6):1005-1009(2009)\nDschietzig, T., et al. Regul. Pept. 155 (1-3), 163-173 (2009) :\nMookerjee, I., et al. FASEB J. 23(4):1219-1229(2009)\nSvendsen, A.M., et al. Mol. Cell. Endocrinol. 296 (1-2), 10-17 (2008) :

Additional Info

Human

Alternative Names

RLN2, Prorelaxin H2, Relaxin B chain, Relaxin A chain