Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an �orphan� G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6kD disulfide linked heterodimeric protein consisting of a 24aa A-chain and a 29aa B-chain.
Source:
Recombinant protein corresponding to human Relaxin-2, expressed in E.coli.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
A-Chain: QLYSALANKC CHVGCTKRSL ARF B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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