Home  >  Products  >  RND3, Recombinant, Human (Rho-related GTP-binding Protein RhoE, Protein MemB, Rho Family GTPase 3, Rho-related GTP-binding Protein Rho8, Rnd3, ARHE, RHO8, RHOE)

RND3, Recombinant, Human (Rho-related GTP-binding Protein RhoE, Protein MemB, Rho Family GTPase 3, Rho-related GTP-binding Protein Rho8, Rnd3, ARHE, RHO8, RHOE)

Cat no: R1998-13R


Supplier: United States Biological
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Rho-related GTP-binding protein RhoE, also known as RND3, is a small GTPase of the Ras superfamily that regulate the organization of the actin cytoskeleton in response to extracellular growth factors. RND3 activity leads to a decrease in stress fibers and increased cell migration, at least in part through regulation of the Rho-dependent kinase ROCK1. Also, RND3 has been implicated in inhibition of DNA-damage induced apoptosis and cell cycle arrest. Source: Recombinant corresponding to aa1-241 of human RND3 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS C Molecular Weight: 29.2kD (261aa) confirmed by MALDI-TOF Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: R1998-13R
Size: 100ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 40% glycerol, 1mM EDTA, 0.1M sodium chloride.
Purity: ~90% (SDS-PAGE).
References: 1. Riento K., et al. (2005) Mol Cell Biol. 23:4219-29. 2. Boswell S A., et al. (2007) J Biol Chem. 282:4850-8.

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