RPC8, NT (POLR3H, KIAA1665, RPC8, DNA-directed RNA polymerase III subunit RPC8, DNA-directed RNA polymerase III subunit H, RNA polymerase III subunit 22.9kD subunit) (FITC)

RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.\n\nApplications:\nSuitable for use in Western Blot, Flow Cytometry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nFlow Cytometry: 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze FITC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

041181-FITC

Size

200ul

Applications

ELISA, FC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to FITC.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Greco-Stewart, V.S., et al. Virology 386(1):12-15(2009)\nCollins, J.E., et al. Genome Biol. 5 (10), R84 (2004) \nHu, P., et al. Mol. Cell. Biol. 22(22):8044-8055(2002)

Additional Info

Human, mouse

Alternative Names

POLR3H, KIAA1665, RPC8, DNA-directed RNA polymerase III subunit RPC8, DNA-directed RNA polymerase III subunit H, RNA polymerase III subunit 22.9kD subunit