RSK3, Active (RSK-3, RSK 3, Active RSK3, RSK3, RSK, human RSK3, active kinase, active kinases, recombinant RSK, recombinant RSK3, kinase activity assay, protein kinase)

RSK3 is a member of the RSK (ribosomal S6 kinase) family that encodes a 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal. RSK3 mRNA is widely expressed and is activated by growth factors, serum and phorbol ester. Upon stimulation, RSK3 translocates to the cell nucleus and phosphorylates nuclear proteins. RSK3 can bind to ERK1/2 and this association increases the duration of RSK3 activation.\n\nSource:\nRecombinant protein corresponding to human RSK3 expressed in Sf9 insect cells.\n\nMolecular Weight: \n~112.0kD\n\nBiological Activity:\nThe specific activity of RSK3 was determined to be 131nmol /min/mg as per activity assay protocol.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

167958

Size

5ug

Form

Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Purity

~90% (SDS-PAGE)

References

1.Zhao, Y. et al: RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol. 1995 Aug;15(8):4353-63.\n2.Roux, P P. et al: Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003 Jul;23(14):4796-804.