Home  >  Products  >  RSPO3 (R-spondin-3, Protein with TSP Type-1 Repeat, hPWTSR, Roof Plate-specific Spondin-3, hRspo3, Thrombospondin Type-1 Domain-containing Protein 2, PWTSR, THSD2)
RSPO3 (R-spondin-3, Protein with TSP Type-1 Repeat, hPWTSR, Roof Plate-specific Spondin-3, hRspo3, Thrombospondin Type-1 Domain-containing Protein 2, PWTSR, THSD2)

RSPO3 (R-spondin-3, Protein with TSP Type-1 Repeat, hPWTSR, Roof Plate-specific Spondin-3, hRspo3, Thrombospondin Type-1 Domain-containing Protein 2, PWTSR, THSD2)

Cat no: R9417-52B

Supplier: United States Biological
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Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 0.3-1ug/ml, human skeletal muscle lysates observed on ~28kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: R9417-52B
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human RSPO3. Species sequence homology: Bovine, canine, mouse and rat.

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