Rugulosin ((+)-Rugulosin, NSC 160880, NSC 249990, Radicalisin)

Antibiotic. \nAntibacteriophage. Antiviral. \nMycotoxin. \nDNA replication, transcription and repair inhibitor. \nAntibacterial. \nRNA polymerase and ribonuclease H inhibitor. \nInsecticidal. Cytotoxic. \nHIV-1 integrase inhibitor. \nShows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity. \n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 3 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045263

Size

250ug

Purity

>95% (HPLC)

References

Product Reference: \n?Studies in the biochemistry of micro-organisms. 95. Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom: J. Breen, et al.; Biochem. J. 60, 618 (1955)\n?Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect: S. Nakamura, et al.; Jpn. J. Microbiol. 15, 113 (1971)\n?Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom: Y. Ueno, et al.; Jpn. J. Exp. Med. 41, 177 (1971)\n?Specific and non-specific interactions of two carcinogenic mycotoxins, luteoskyrin and rugulosin with nucleic acids: J.C. Bouhet, et al.; Ann. Nutr. Aliment. 31, 811 (1977)\n?Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum: A.A. Stark, et al.; J. Environ. Pathol. Toxicol. 2, 313 (1978)\n?Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H: F. Tashiro, et al.; Appl. Environ. Microbiol. 38, 191 (1979)\n?Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): possible agents for biological control: P. Watts, et al.; Mycol. Res. 107, 581 (2003)\n?Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites: S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol. 30, 721 (2003)\n?New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2: H. Yamazaki, et al.; Org. Lett. 12, 1572 (2010)\n?

Alternative Names

(+)-Rugulosin, NSC 160880, NSC 249990, Radicalisin