RUNX3 (Runt-related Transcription Factor 3, Acute Myeloid Leukemia 2 Protein, AML2, CBFA3, CBF-alpha-3, Core-binding Factor Subunit alpha-3, Oncogene AML-2, PEA2-alpha C, PEBP2A3, PEBP2aC, PEBP2-alpha C, Polyomavirus Enhancer-binding Protein 2 alpha C Sub

RUNX3, also called CBFA3, AML-2 or PEBP2-aC, is a member of the Runt domain family of nuclear transcriptional regulators. All of the RUNX proteins form dimers with CBF-b. The runt domain (aa54-186) is required for DNA binding, while a Pro/Ser/Thr-rich region (aa191-415) transcriptionally activates target genes. Isoform 2 has an alternate 19aa sequence in place of the N-terminal 5aa of isoform 1. The 415aa human RUNX3 shows 91% aa identity with mouse or rat RUNX3. RUNX3 is necessary for growth control of gastric epithelium, neurogenesis of dorsal root ganglia, and T cell differentiation. RUNX3 expression is frequently mutated in tumors and appears to be silenced by methylation.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul labels 1x10e6\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nFusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, E. coli-derived recombinant human RUNX3.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.

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